Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response

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Both the prevalence and the severity of dry eye disease increase with age. Previous work from our laboratory has established the central role of memory Th17 cells (CD4+IL-17A+CD44+) in driving the chronic and relapsing course of dry eye disease. Here, we investigated the contribution of memory Th17 cells to age-related dry eye disease, and evaluated memory Th17 cell depletion with anti-IL-15 antibody as a strategy to abrogate the severe exacerbations of dry eye disease observed in aged mice. Following initial exposure to desiccating stress, aged mice maintain higher frequencies of memory Th17 cells in the draining lymph nodes relative to young mice.... View the whole article at the The American Journal of Pathology Blog.

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