Antibiotics Can be Used to Contain Drug-resistant Bacteria by Maintaining Sufficiently Large Sensitive Populations
May 25, 2020 | Biology
Always be updated on the latest Biology industry news no matter what. Lab.Equipment is here to provide current articles from trustworthy online sources today. Read this one first published on PLOS Biology, Public Library of Science Biology:
by Elsa Hansen, Jason Karslake, Robert J. Woods, Andrew F. Read, Kevin B. Wood
Standard infectious disease practice calls for aggressive drug treatment that rapidly eliminates the pathogen population before resistance can emerge. When resistance is absent, this elimination strategy can lead to complete cure. However, when resistance is already present, removing drug-sensitive cells as quickly as possible removes competitive barriers that may slow the growth of resistant cells. In contrast to the elimination strategy, a containment strategy aims to maintain the maximum tolerable number of pathogens, exploiting competitive suppression to achieve chronic control. Here, we combine in vitro experiments in computer-controlled bioreactors with mathematical modeling to investigate whether containment strategies can delay failure of antibiotic treatment regimens. To do so, we measured the “escape time” required for drug-resistant Escherichia coli populations to eclipse a threshold density maintained by adaptive antibiotic dosing. Populations containing only resistant cells rapidly escape the threshold density, but we found that matched resistant populations that also contain the maximum possible number of sensitive cells could be contained for significantly longer. The increase in escape time occurs only when the threshold density—the acceptable bacterial burden—is sufficiently high, an effect that mathematical models attribute to increased competition. The findings provide decisive experimental confirmation that maintaining the maximum number of sensitive cells can be used to contain resistance when the size of the population is sufficiently large... Find the complete article at the Public Library of Science Biology, Public Library of Science Biology Blog.
In the Bio industry and are interested in feature-packed Biology lab equipment for your workroom? Shop Lab.Equipment’s variety of Biology products designed and engineered by globally trusted brands such as:
Get valuable Biology equipment available on Lab.Equipment like:
It's not a problem if you are covering other applications. Lab.Equipment has you covered with a variety of multipurpose lab equipment to boost your laboratory productivity and efficiency. Shop accurate and precise equipment for applications like microbiology, environmental, clinical, and more here.