Artificial Proteins Give Living Cells a Computational Upgrade

April 16, 2020 | Biotechnology

Reading time: 3 minutes

To keep you updated on current Bio Technology industry news, Lab.Equipment has curated this interesting article from GEN for you:

Call it Protein Logic Gate 2.0. The 1.0 version, which rewired native signaling pathways, was admirably direct, bypassing awkward rewiring at the DNA and RNA levels, but it wasn’t very scalable or extensible. It relied on a limited pool of building blocks, in this case, native proteins presenting interfaces open to fabricated protein-protein interactions. Artificial proteins can offer more flexibility. They can come in sets of modular units that interact with each other in clearly defined ways to read inputs, complete logical operations, and generate outputs.

The equivalent of Protein Logic Gate 2.0 has been launched by scientists based at the University of Washington School of Medicine. They’ve already run demonstrations of how it can be used to manipulate gene expression. These demonstrations, which involved cell-free extracts... View the full article at the GEN Blog.

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