Asthma Risk Increases in Adults by Mothers Smoking During Pregnancy

May 11, 2020 | Biotechnology

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Today, Lab.Equipment has curated a new Biotechnology article published from Genetic Engineering and Biotechnology News (GEN):

Scientists in Sweden report that smoking by pregnant mothers caused roughly a 1.5-fold asthma risk in their offspring at the ages between 31 and 46. The study “Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years”, which appears in the European Respiratory Journal, is important because exposure to cigarette smoke is known to increase the risk of asthma in childhood, but research findings on its later effects are scarce, according to the team.

“Environmental tobacco smoke exposure (ETS) increases asthma risk in children. There is limited knowledge of prenatal ETS for adult onset asthma. [Our study was performed to] determine the association between prenatal ETS and adult onset asthma,” write the investigators.

Questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by the age 31 years, of Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last three months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring were studied by adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult onset asthma among the offspring (adjusted odds ratio 1.54, 95% confidence interval 1.04–2.29), namely among offspring who reported either past non-diagnosed asthma (odds ratio 9.63, 95% confidence interval 2.28–40.67), or past cough with wheeze (3.21, 95% CI 1.71–6.05). Significant association was detected between gestational smoke exposure and offspring’s FEV1/FVC ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1 gestational smoke exposure was associated with adult onset asthma (5.53, 95% CI 2... View the entire article at the GEN – Genetic Engineering and Biotechnology News Blog.

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