Atrophy and Death of Non-peptidergic and Peptidergic Nociceptive Neurons in SIV Infection

For your weekly Pathology news, Lab.Equipment has curated this article from The American Journal of Pathology for you:

Human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) is a common neurological comorbidity of HIV infection and prevails in the post-antiretroviral therapy (ART) era. HIV infection drives pathologic changes in the dorsal root ganglia (DRG) through inflammation, altered metabolism, and neuronal dysfunction. Here, we characterized specific neuronal populations in a simian immunodeficiency virus (SIV)-infected macaque model with or without ART. DRG neuronal populations were identified by neurofilament H-chain 200 (NF200), I-B4 isolectin (IB4), or tropomyosin receptor kinase A (TrkA) expression and assessed for cell body diameter, population size, apoptotic markers, and regeneration signaling.... More of this in the The American Journal of Pathology Blog.

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