Atrophy and Death of Non-peptidergic and Peptidergic Nociceptive Neurons in SIV Infection
April 17, 2020 | Histopathology
For your weekly Pathology news, Lab.Equipment has curated this article from The American Journal of Pathology for you:
Human immunodeficiency virus (HIV)-associated sensory neuropathy (HIV-SN) is a common neurological comorbidity of HIV infection and prevails in the post-antiretroviral therapy (ART) era. HIV infection drives pathologic changes in the dorsal root ganglia (DRG) through inflammation, altered metabolism, and neuronal dysfunction. Here, we characterized specific neuronal populations in a simian immunodeficiency virus (SIV)-infected macaque model with or without ART. DRG neuronal populations were identified by neurofilament H-chain 200 (NF200), I-B4 isolectin (IB4), or tropomyosin receptor kinase A (TrkA) expression and assessed for cell body diameter, population size, apoptotic markers, and regeneration signaling.... More of this in the The American Journal of Pathology Blog.
In the Pathology industry and are in the lookout for premium Pathology lab equipment for your laboratory? Shop Lab.Equipment’s extensive selection of Histopath equipment manufactured by major manufacturers like Radwag and Hermle -- from centrifuges, pipettes, balances and more here.
Running other applications? You can count on Lab.Equipment for much needed assistance. Improve workroom efficiency and productivity with lab equipment for other industries including microbiology, environmental, clinical, and more. Check out what you need for your application here.