B7-H3 Immune Checkpoint Expression is a Poor Prognostic Factor in Colorectal Carcinoma

Originally published on Modern Pathology, check out what Lab.Equipment has sourced for your Histopath industry news fix:

Although PD-1/PD-L1 immunotherapy has been used successfully in treating many cancers, metastatic colorectal cancer (CRC) patients are not as responsive. B7-H3 is a promising target for immunotherapy and we found it to have the highest expression among B7-CD28 family members in CRC. Thus, the aim of the present study was to investigate B7-H3 expression in a large CRC cohort. B7-H3, B7-H4, and PD-L1 protein levels and differential lymphocyte infiltration were evaluated in tissue microarrays from 805 primary tumors and matched metastases. The relationships between immune markers, patient characteristics, and survival outcomes were determined. B7-H3 (50.9%) was detected in more primary tumors than B7-H4 (29.1%) or PD-L1 (29.2%), and elevated B7-H3 expression was associated with advanced... Find the whole article at the Modern Pathology Blog.

If you are in the Histopath industry and are in the lookout for feature-packed Pathology equipment for tissue staining or specimen collection or basic and advanced applications, then you have come to the right place. Lab.Equipment provides an extensive selection of equipment for workrooms running histophatological tests. Browse our recommended Pathology equipment like:

• Laboratory Mixers
• Laboratory Centrifuges
• Lab Pipettes
• Stirrers
• Laboratory Balances

We supply a portfolio of products made by established MFGs including:

• Aczet
• Radwag
• Troemner
• Scilogex

Focusing on other applications? You can count on Lab.Equipment for much needed help. Enhance facility productivity with lab equipment for other industries including veterinary, chemistry, forensics, and more. Find what you require for your application here.