Base Editing Gene Therapy Restores Hearing in Mice

June 10, 2020 | Biotechnology

Reading time: 3 minutes

Today, Lab.Equipment has sourced a new Bio Tech article published from GEN just for you:

Current treatments for hearing loss focus on amplifying sound, rather than targeting the cause of the disease. Now, a team of researchers report the use of base editors to treat Baringo mice—a mouse model of recessive genetic deafness caused by a point mutation in the transmembrane channel-like 1 gene Tmc1. This method, which is the first example of repairing a recessive gene mutation, restored hair cell sensory transduction and partial hearing. 

Details about the approach are published in the paper, “In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness,” in Science Translational Medicine.

Base editing is a technique developed by the lab of Da... Read more at the Genetic Engineering and Biotechnology News (GEN) Blog.

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