Blocking Thrombospondin-1 signaling via CD47 Mitigates Renal Interstitial Fibrosis

May 27, 2020 | Histopathology

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Thrombospondin-1 (TSP1) is a matrix protein that binds it high affinity receptor CD47. Both TSP1 and CD47 are upregulated in the kidney in response to injury and this promotes the development of fibrosis by inducing transforming growth factor-β and other fibrogenic factors. The authors were able to block or eliminate CD47-based signal transduction to reduce renal fibrosis... Want to read more? Visit the Laboratory Investigation​ Blog.

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