Cellular Stress Causes Cancer Cell Chemoresistance

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There is a broad range of mechanisms associated with chemoresistance, many of which to date are only poorly understood. The so-called cellular stress response—a set of genetic programs that enable the cells to survive under stressful conditions—plays a key role in the development of numerous diseases and in chemoresistance. A better understanding of the cellular stress response pathways is therefore urgently required to develop new therapeutic concepts to overcome chemoresistance. "In this context, we employed comprehensive analytical approaches to gain deep and molecular insight into the Unfolded Protein Response, a cellular stress reaction induced by unfolded proteins," says Robert Ahrends, group leader at the Department of Analytical Chemistry of the Faculty of Chemistry... Read more of this in the Phys.Org Blog.

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