Compensatory Changes in Villus Morphology of Lactating Mus musculus in Response to Insufficient Dietary Protein

April 22, 2020 | Biology

No need to search high and low for current Bio industry news as Lab.Equipment guarantees you are updated no matter where you are. This week’s article comes from Journal of Experimental Biology (JEB):

Kay Short and Elissa M. Derrickson

Energetic challenges match intestinal size to dietary intake but less is known about how the intestine responds to specific macronutrient challenges. We examined how intestinal size responds to insufficient dietary protein at the microscopic level. Villi, enterocytes and surface area were measured across the length of the small intestine in non-reproductive and lactating Mus musculus fed isocaloric control or protein-deficient diets. Lactating mice on the protein-deficient diet exhibited a 24% increase in villus height and a 30% increase in enterocyte width in the proximal small intestine and an overall similar increase in surface area; on the control diet, changes in villus height were localized in the mid region. Flexibility localized to the proximal small intestine suggests that enterokinase, a localized enzyme, may be a candidate enzyme that promotes compensation for a protein-deficient diet. Such flexibility could allow s... Read more at the Journal of Experimental Biology Blog.

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