Discoidin Domain Receptor 1 (DDR1) is Necessary for Tissue Homeostasis in Pancreatic Injury and Pathogenesis of Pancreatic Ductal Adenocarcinoma
May 01, 2020 | Histopathology
Lab.Equipment is always here to make sure you are informed on the latest Pathology industry news. Here is what we have sourced from The American Journal of Pathology today for you:
Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis (CP) are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by collagens that can regulate cell proliferation, migration, adhesion, and remodeling of the extracellular matrix (ECM). To address the role of DDR1 in PDA, we crossed DDR1-null (DDR1-/-) mice into the KrasG12D/+; Trp53R172H/+; Ptf1aCre/+ (KPC) model of metastatic PDA. We found that DDR1-/-; KPC mice progress to differentiated PDA, but resist progression to poorly-differentiated cancer, compared to KPC control mice.... Read the entire article at the The American Journal of Pathology Blog.
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