Downregulation of Mitochondrial Metabolism After Tendon Release Primes Lipid Accumulation in Rotator Cuff Muscle

April 29, 2020 | Histopathology

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Atrophy and fat accumulation is a debilitating aspect of muscle diseases that it is rarely prevented. Using a vertical approach combining anatomical with omics methodology in a tenotomy-induced sheep model for rotator cuff disease, we tested whether mitochondrial dysfunction is implicated in muscle wasting and perturbed lipid metabolism; speculating that both can be prevented by the stimulation of beta-oxidation with L-carnitine.Infraspinatus muscle lost 22% of its volume over the first six weeks after tenotomy before the area percentage of lipid increased from 8% to 18% at week sixteen.... You can find the whole article in  The American Journal of Pathology Blog.

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