Early Correction of Synaptic Long-term Depression Improves Abnormal Anxiety-like Behavior in Adult GluN2B-C456Y-mutant Mice

Lab.Equipment has your daily Bio industry news fix covered. Here is today's article first published on Public Library of Science Biology:

by Wangyong Shin, Kyungdeok Kim, Benjamin Serraz, Yi Sul Cho, Doyoun Kim, Muwon Kang, Eun-Jae Lee, Hyejin Lee, Yong Chul Bae, Pierre Paoletti, Eunjoon Kim

Extensive evidence links Glutamate receptor, ionotropic, NMDA2B (GRIN2B), encoding the GluN2B/NR2B subunit of N-methyl-D-aspartate receptors (NMDARs), with various neurodevelopmental disorders, including autism spectrum disorders (ASDs), but the underlying mechanisms remain unclear. In addition, it remains unknown whether mutations in GluN2B, which starts to be expressed early in development, induces early pathophysiology that can be corrected by early treatments for long-lasting effects. We generated and characterized Grin2b-mutant mice that carry a heterozygous, ASD-risk C456Y mutation (Grin2b^+/C456Y). In Grin2b^+/C456Y mice, GluN2B protein levels were strongly reduced in association with decreased hippocampal NMDAR currents and NMDAR-dependent long-term depression (LTD) but unaltered long-term potentiation, indicative of mutation-induced protein degradation and LTD sensitivity. Behaviorally, Grin2b^+/C456Y mice showed normal social interaction but exhibited abnormal anxiolytic-like behavior. Importantly, early, but not late, treatment of young Grin2b^+/C456Y mice with the NMDAR agonist D-cycloserine rescued NMDAR currents and LTD in juvenile mice and improved anxiolytic-like behavior in adult mice. Therefore, GluN2B-C456Y haploinsufficiency decreases GluN2B protein levels, NMDAR-dependent LTD, and anxiety-like behavior, and early activation of NMDAR function has long-lasting effects on adult mouse behavior... Want to read more? View the entire article in the Public Library of Science Biology Blog.

Working on Bio applications like food production or medicine and are keeping an eye on top quality Biology lab equipment to complete demands of your facility? Shop Lab.Equipment’s selection of Bio products designed and built by well-recognized brands such as:

• Radwag
• Accuris
• Ohaus
• Scilogex
• Being Instrument

Get exceptional Biology equipment available on Lab.Equipment like:

• Lab Balances
• Stirrers
• Laboratory Shakers
• Centrifuges
• Lab Pipettes

You can also depend on Lab.Equipment for a range of fully-featured equipment best for applications such as veterinary, chemistry, forensics, and more. Raise your workwoom efficiency and productivity by getting precise and accurate laboratory equipment here.