Endoplasmic Reticulum Stress Signaling in Cancer Cells

April 16, 2020 | Histopathology

There is no need to search at great lengths for current Pathology industry news as Lab.Equipment ensures you’re updated no matter where you are. This week’s curated article is fresh from The American Journal of Pathology:

To survive, cancers cells must resist numerous internal and environmental insults associated with neoplasia that jeopardize proteostasis within the endoplasmic reticulum (ER). Solid and hematopoietic tumors often experience genomic instability, oncogene activation, increased protein secretion demands, and somatic mutations in proteins handled by the secretory pathway that impede their folding. Invasion or metastasis into foreign environments can expose tumor cells to hypoxia, oxidative stress, lack of growth signals, inadequate amino acid supplies, glucose deprivation, and lactic acidosis, all of which pose challenges for protein processing in the ER.... View the full article at the The American Journal of Pathology Blog.

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