Engineered Bacteria Demonstrate Antitumor Activity in Mice

June 11, 2020 | Biotechnology

Reading time: 2-3 minutes

For your daily Biotechnology news, Lab.Equipment has sourced this interesting article from GEN – Genetic Engineering and Biotechnology News for you:

Creating “living medicines” is one goal of the synthetic biology field. These therapeutics could take many forms, one of which is bacteria that are created to address the underlying drivers of disease. Now, the company Synlogic has published data on the preclinical development of SYNB1891, which is being developed as a living biotherapeutic as a clinical immuno-oncology program for the treatment of cancer. The therapeutic is being evaluated in a Phase I clinical trial in patients with advanced solid tumors or lymphoma.

The work is published in Nature Communications in a paper titled, “Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity.” Data described in the publication demonstrate that SYNB1891 treatment cleared tumors and stimulated antitumor immunity in preclinical models of cancer.

“The targeted delivery and dual immune stimulatory activity of SYNB1891 offer distinct advantages over other approaches,” said Aoife Brennan, MB, ChB, Synlogic’s president and chief executive officer. “The preclinical data published today highlight the transformative potential of SYNB1891. Together with the early experience in the clinic demonstrating feasibility and tolerability in the initial cohorts of the clinical trial, these data provide support for the continued development of SYNB1891 as a potential therapeutic option to expand the benefits of immunotherapy to more patients with cancer.”

The paper details the engineering and characterization of SYNB1891, describes preclinical studies that demonstrate antitumor activity and generation of immunological memory by SYNB1891 in mouse models of cancer, as well as its robust activation of human antigen-presenting cells (APCs) that are key to the generation of an antitumoral immune response.

The team of scientists used nonpathogen... More of this in the GEN – Genetic Engineering and Biotechnology News Blog.

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