Erythropoietin Receptor Signaling Supports Retinal Function after Vascular Injury
May 11, 2020 | Histopathology
Fresh off The American Journal of Pathology, Lab.Equipment has sourced this noteworthy Pathology industry article just for you:
The investigation of erythropoietin (EPO) has expanded to include potential nonhematopoietic roles in neural and retinal diseases, including diabetic retinopathy. However, it remains unclear how EPO functions to support the neural retina. Transgenic mice with hypoactive EPO receptor (EPOR) signaling (hWtEPOR) were compared with littermate control mice (WT) to test the role of EPOR signaling under normal conditions and after vascular injury and regrowth into the retina. Although retinal function tested with OptoMotry and electroretinography was comparable to adult (8-week–old) littermate WT mice, hWtEPOR mice had thinner inner and outer plexiform layers and a greater number of amacrine cells.... View the entire article at the The American Journal of Pathology Blog.
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