Abundant evidence has shown metabolic benefits of fasting. However, a new mechanistic study conducted on mouse models from the Icahn School of Medicine at Mount Sinai, provided a word of caution that skipping meals might pose detrimental health risks that could lead to heart disease. They exhibited the fundamental biology relevant to fasting and how it triggers a response in the brain that negatively impacts immune cells.
The researchers particularly looked at how chronic fasting can affect the immune system long term. They tested two groups of mice: one group ate breakfast while the other did not. They collected blood samples in both groups every time they woke up (baseline), four hours later, and then eight hours.