Fibroblast Activation Protein Regulates Lesion Burden and the Fibro-inflammatory Response in Apoe-deficient Mice in a Sexually Dimorphic Manner

April 17, 2020 | Histopathology

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Fibroblast activation protein (FAP) has been established as an inducible and mesenchymal cell-specific mediator of disease progression in cancer and fibrosis. Atherosclerosis is a fibro-inflammatory disease, and FAP was previously reported to be up-regulated in human atherosclerotic plaques compared to normal vessel. Here, we investigated the spatial and temporal distribution of Fap expressing cells in a murine model of atherosclerosis and used a genetic approach to determine if and how Fap impacted disease progression.... Want to read more? Read the full article in the The American Journal of Pathology Blog.

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