Filoviruses Infect Rhesus Macaque Synoviocytes In Vivo and Primary Human Synoviocytes In Vitro

Lab.Equipment sees to it that you get your everyday Histopathology news fix whenever you want it. Check out today’s article curated from a credible online source, The American Journal of Pathology:

The most commonly reported symptom of post-Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection has not been well-characterized in human patients or animal models. By immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by Ebola virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model. Further, we demonstrate by histology, immunohistochemistry, RNAscope in situ hybridization, and transmission electron microscopy that synoviocytes of the stifle, shoulder, and hip are a target for mouse-adapted Ebola virus/Yambuku-Mayinga infection during acute disease in rhesus macaques... Read the full article at The American Journal of Pathology Blog.

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