Genetic Mechanism Behind Inflammatory Bowel Disease Discovered

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Scientists at Children’s Hospital of Philadelphia (CHOP) say they have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target. The findings, “Regulation of Janus Kinase 2 by an Inflammatory Bowel Disease Causal Non-coding Single Nucleotide Polymorphism,” are published in the Journal of Crohn’s and Colitis.

“Among the >240 genetic loci described to date which confer susceptibility to inflammatory bowel disease, a small subset has been fine-mapped to an individual, non-coding single nucleotide polymorphism [SNP]. To illustrate a model mechanism by which a presumed-causal non-coding SNP can function, we analyzed rs1887428, located in the promoter region of the Janus kinase 2 [JAK2] gene. We utilized comparative affinity purif... Want to read more? Visit the Genetic Engineering and Biotechnology News (GEN)​ Blog.

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