Genome Editing Helps Cell Lines “Clean Up” Their Protein Production

May 18, 2020 | Biotechnology

Reading time: 3-4 minutes

Lab.Equipment has curated a new article from the Biotech industry for you. This one is published by GEN – Genetic Engineering and Biotechnology News:

If you want to “clean up” in the recombinant protein business, you might want to start by sweeping away process-related impurities, specifically, host cell proteins (HCPs). Undesirable HCPs are generated by host cells along with desirable biotherapeutic proteins, increasing metabolic demand, degrading product quality, and contaminating the final product. They also necessitate troublesome (and expensive) purification procedures.

In other words, you can clean up now, or clean up later. To make “now” an option, researchers from the University of California San Diego (UCSD) and the Danish Technical University (DTU) have introduced a broom of sorts: a CRISPR-Cas-mediated gene editing approach that can eliminate up to 70% of the contaminating protein by mass in recombinant-protein drugs.

The researchers demonstrated the value of cleanliness in mammalian cells—Chinese hamster ovary (CHO) cells. By using CRISPR-Cas to disrupt multiple genes and thereby suppress the production of HCPs, the researchers achieved a significant decrease in purification demands across the CHO cell lines they investigated. Such tidiness, the researchers suggested, could lead to lower production costs and higher quality drugs... Read more at the GEN – Genetic Engineering and Biotechnology News Blog.

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