H2 Histamine Receptor Vivo-Morpholino Treatment Ameliorates Large Bile Duct Damage in Mice Deficient in ATP Binding Cassette Subfamily B Member 4 (Abcb4-/-) via Down-regulation of cAMP/ERK Signaling
May 15, 2020 | Histopathology
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Histamine binds to one of the four G-protein–coupled receptors expressed by large cholangiocytes. Histamine specifically increases large cholangiocyte proliferation via H2 histamine receptor (H2HR), which is increased in patients with primary sclerosing cholangitis (PSC). Ranitidine decreases liver damage in Mdr2-/- (Abcb4 null) mice. We targeted hepatic H2HR in Mdr2-/- mice using Vivo-Morpholino. Wild-type and Mdr2-/- mice were treated with mismatch or H2HR Vivo-Morpholino by tail vein injection for one week... Want to read more? Visit the The American Journal of Pathology Blog.
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