Haplotype of the Astrocytic Water Channel AQP4 is Associated with Slow Wave Energy Regulation in Human NREM Sleep

Lab.Equipment has your daily Biology news covered. Check out this one sourced from PLOS Biology:

by Sara Marie Ulv Larsen, Hans-Peter Landolt, Wolfgang Berger, Maiken Nedergaard, Gitte Moos Knudsen, Sebastian Camillo Holst

Cerebrospinal fluid (CSF) flow through the brain parenchyma is facilitated by the astrocytic water channel aquaporin 4 (AQP4). Homeostatically regulated electroencephalographic (EEG) slow waves are a hallmark of deep non–rapid eye movement (NREM) sleep and have been implicated in the regulation of parenchymal CSF flow and brain clearance. The human AQP4 gene harbors several single nucleotide polymorphisms (SNPs) associated with AQP4 expression, brain-water homeostasis, and neurodegenerative diseases. To date, their role in sleep-wake regulation is unknown. To investigate whether functional variants in AQP4 modulate human sleep, nocturnal EEG recordings and cognitive performance were investigated in 123 healthy participants genotyped for a common eight-SNP AQP4-haplotype. We show that this AQP4-haplotype is associated with distinct modulations of NREM slow wave energy, strongest in early sleep and mirrored by changes in sleepiness and reaction times during extended wakefulness. The study provides the first human evidence for a link between AQP4, deep NREM sleep, and cognitive consequences of prolonged wakefulness... Read more of this in the PLOS Biology Blog.

Administering Bio applications like food production or cultivation and canvassing for reliable Bio lab equipment? You can depend on Lab.Equipment for a variety of Bio products from globally recognized brands including:

• Ohaus
• AnD Weighing
• Being Instrument
• Radwag
• Accuris

Get a hold of valuable and user-friendly products highly recommended for basic and advanced Bio applications by browsing our product inventory of:

• Analytical Balances
• Laboratory Mixers
• Centrifuges
• Lab Pipettes
• Laboratory Stirrers

Fulfilling microbiology, environmental, clinical applications? Rely on Lab.Equipment to boost your efficiency and productivity. Get accurate lab equipment no matter for what application here.