High Levels of Chromosomal Copy Number Alterations and TP53 Mutations Correlate with Poor Outcome in Younger Breast Cancer Patients

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Prognosis for young patients with breast cancer is generally poor, yet considerable differences in clinical outcome between individual patients exist. To understand the genetic basis of the disparate clinical courses, we collected tumors from 34 younger women, 17 with good and 17 with poor outcomes, as determined by disease-specific survival during a follow-up period of 17 years. The clinicopathological parameters of the tumors were complemented with DNA image cytometry profiles, enumeration of copy numbers of eight breast cancer genes by multicolor fluorescence in situ hybridization, and targeted sequence analysis of 563 cancer genes.... More of this in The American Journal of Pathology Blog.

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