Histone H2B Induces Retinal Ganglion Cell Death Through Toll-like Receptor 4 in the Vitreous of Acute Primary Angle Closure Patients

May 05, 2020 | Histopathology

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Increased levels of histone H2B (H2B), a damage-associated protein, are found in the vitreous of patients with acute primary angle closure. Elevated H2B causes severe inflammation and subsequent retinal ganglion cell death through toll-like receptor 4 (TLR4) signaling. These results provide new insight for the mechanism of retinal ganglia degeneration.... Want to read more? Visit the Laboratory Investigation​ Blog.

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