Immunogradient Indicators for Anti-tumor Response Assessment by Automated Tumor-stroma Interface Zone Detection

April 17, 2020 | Histopathology

Handpicked by Lab.Equipment from The American Journal of Pathology, here is this week's Pathology industry article for you:

The distribution of tumor infiltrating lymphocytes (TIL) within the tumor microenvironment provides strong prognostic value, which is increasingly important with the arrival of new immunotherapy modalities. Both visual and image analysis based assays are developed to assess the immune contexture of the tumors. We propose an automated method based on grid-subsampling of microscopy image analysis data to extract the tumor-stroma interface zone (IZ) of controlled width. The IZ is a ranking of tissue areas by their distance to the tumor edge which is determined by a set of explicit rules.... More of this in the The American Journal of Pathology Blog.

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