Induction of Steatohepatitis and Liver Tumorigenesis by Enforced Snail Expression in Hepatocytes

April 20, 2020 | Histopathology

No need to search at great lengths for current Histopathology industry news as Lab.Equipment guarantees you’re updated whenever and wherever. This week’s article comes from The American Journal of Pathology:

Snail is a transcription factor that regulates many cellular events involved in development, homeostasis, and disease. In hepatocellular carcinoma (HCC), Snail induces epithelial-to-mesenchymal transition that confers invasive properties on tumor cells during HCC progression and malignancy. Snail activation observed in HCC mouse models suggests its involvement in not only progression, but also onset of HCC. However, it remains unclear whether Snail directly contributes to HCC initiation or whether it supports HCC initiation promoted by other oncogenes.... Want to read more? Visit the The American Journal of Pathology​ Blog.

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