Inhibition of miR-181a-5p Reduces Astrocyte and Microglia Activation and Oxidative Stress by Activating SIRT1 in Immature Rats with Epilepsy

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This study reveals that inhibition of miR-181a-5p protects immature rats from epilepsy, including hippocampal insults, neuronal apoptosis, astrocyte and microglia activation, neuroinflammation, and oxidative stress. This protection is achieved through the SIRT1 pathway, which may be a novel therapeutic target for epilepsy... You can find the full article in the Laboratory Investigation Blog.

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