Integrin β4 Is an Effective and Efficient Marker in Synchronously Highlighting Lymphatic and Blood Vascular Invasion, and Perineural Aggression in Malignancy

April 28, 2020 | Histopathology

Lab.Equipment makes sure that you get your regular Surgical Pathology news fix no matter what. Read today’s article that first appeared on AJSP:

Lymphovascular invasion (LVI) and perineural invasion (PNI) are 2 important pathologic parameters and need to be accurately assessed in multiple malignancies. Integrin β4, a member of the integrin family, has been reported to be positively expressed in vascular endothelia, peripheral nerves, and a collection of epithelia. However, little is known about the effectiveness of β4 immunostaining on the recognition of LVI and PNI. Herein, we explored the applicability of β4 immunostaining in stomach, thyroid, and breast cancers. Parallel immunostaining of D2-40, CD34, and S-100 was performed as controls for lymphatic endothelia, vascular endothelia, and neural fibers, respectively. The results demonstrated that β4 concurrently stained the lymphatic and vascular endothelia, and the peripheral nerves. Both LVI and PNI were clearly and accurately outlined by β4 immunostaining. β4 was also expressed in the majority of tumor cells, enabling recognition of LVI and PNI encroached by small tumor clusters. In contrast to D2-40 and CD34, β4 staining was not observed in stromal cells, and therefore it facilitated differentiation between the shrinkage cleft and LVI. According to our results, β4 staining strikingly increased the diagnostic accuracy and interobserver concordance for LVI and PNI compared with hematoxylin and eosin staining alone. Finally, the applicability of β4 was confirmed in 9 other types of malignancies, including cancers of the colon, prostate, esophagus, lung, kidney, uterus, tongue, bladder, and liver. Collec... More of this in the AJSP Blog.

Tackling Surgical Pathology applications like tissue staining or specimen handling and scouting for quality Pathology lab equipment? Trust Lab.Equipment for a selection of lab products from well-trusted brands including:

Check out multifunction and user-friendly products recommended for numerous histopath tests by browsing our product inventory of:

Dealing with other scientific or industrial applications? No need to worry. We have you covered. Go though our range of reliable lab equipment for veterinary, forensics, microbiology applications and more.

Back To Top
We are fully compliant with the GDPR laws. We promise to safeguard your data and protect your privacy rights.