L1CAM–ILK–YAP Mechanotransduction Drives Proliferative Activity of Epithelial Cells in Middle Ear Cholesteatoma

Curated by Lab.Equipment from The American Journal of Pathology, here is an interesting Histopathology industry news for you:

Middle ear cholesteatoma (cholesteatoma) is a chronic otitis media with an enhanced proliferation of epithelial cells. Negative pressure in the middle ear is thought to be an important factor related to the etiology of cholesteatoma. However, the mechanism of cholesteatoma formation remains unclear.Integrin-linked kinase (ILK), an important modulator of actin cytoskeletal dynamics, interacts with extracellular matrix and results in the upregulation of mechanotransduction effector Yes-associated protein (YAP).... More of this in The American Journal of Pathology Blog.

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