Link between ‘stuck’ stem cells to graying hair
June 02, 2023 | Histopathology
During aging, stem cells that have the ability to move between growth compartments in hair follicles get stuck. This leads to losing the ability to mature and maintain hair color, suggests a new study by the NYU Langone Health and NYU Grossman School of Medicine research team.
The more the hair ages, sheds, and regenerates, a growing number of McSCs get stuck in the hair follicle bulge where they remain and do not mature. These McSCs cannot go back to their original location in the germ compartment where WNT proteins prod them to become pigment cells. Thus, it is the loss of chameleon-like function in melanocytes that leads to the loss of hair color.
These findings illustrate a potential pathway for reversing or preventing the graying of hair in humans by melanocyte stem cell motility and reversible differentiation.