M2 Macrophages and Phenotypic Modulation of Intestinal Smooth Muscle Cells Characterize Inflammatory Stricture Formation in the Rat
June 01, 2020 | Histopathology
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The progression of Crohn’s disease to intestinal stricture formation is poorly controlled and the pathogenesis is unclear, although increased smooth muscle mass is present. Earlier, stricture formation was described in in the rat model of TNBS-induced colitis, now re-examined for early cellular features of stricture development.While inflammation of the mid-descending colon typically resolved, a subset showed characteristic stricturing by Day 16, with an inflammatory infiltrate in the neuromuscular layers that included eosinophils, CD3-positive T cells and CD68-positive macrophages... Read the whole article at The American Journal of Pathology Blog.
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