Malignant Gastrointestinal Neuroectodermal Tumor: Clinicopathologic, Immunohistochemical, and Molecular Analysis of 19 Cases

Reading time: 1 minute

No need to search at great lengths for current Pathology industry news as Lab.Equipment ensures you’re updated wherever and whenever. This week’s curated article is fresh from AJSP:

A malignant gastrointestinal neuroectodermal tumor (GNET) is rare, and it is therefore yet to be completely understood. This study aimed to present the clinicopathologic features of GNET, including treatment information. We included 19 patients with GNET with a mean tumor size of 4.2 cm. The most common site of tumor origin was the small intestine (57.9%), followed by the stomach (15.8%), colon (10.5%), ileocecal junction (5.3%), lower esophagus (5.3%), and anal canal (5.3%). Microscopically, the tumors were composed of epithelioid cells with eosinophilic or clear cytoplasm arranged in nest, sheet-like, papillary, or pseudoalveolar patterns and/or spindle tumor cells with eosinophilic cytoplasm arranged in a fascicular pattern. Immunohistochemically, the tumor cells stained positively for S100 (19/19,100%), SOX10 (14/15, 93.3%), vimentin (17/17, 100%), synaptophysin (Syn) (7/17, 41.2%), CD56 (4/13, 30.8%), CD99 (1/5, 20%), and CD117 (1/15, 6.7%), and negatively for HMB45, Melan A, DOG1, CD34, AE1/AE3, CAM5.2, chromogranin A, smooth muscle actin, and desmin. In total, 14/15 (93.3%) cases showed split Ewing sarcoma breakpoint region 1 gene (EWSR1) signals consistent with a chromosomal translocation involving EWSR1. Within a mean follow-up of 29.7 months (range: 3 to 63 mo), 2/15 (13.3%) patients died of disease, 5 (33.3%) were alive with disease, and 8 (53.3%) had no evidence of disease. Two and 1 patients showed partial response to apatinib and anlotinib, respectively. In conclusion, GNET has distinctive morphologi... More of this in the AJSP Blog.

If you're in the Surgical Pathology industry and are in the lookout for multipurpose Surgical Pathology equipment for specimen handling or tissue preparation, basic or advanced applications, then you have come to the right place. Lab.Equipment supplies a range of equipment for laboratories running histopath tests. Browse our highly-recommended Pathology equipment like:

• Precision Scales
• Lab Stirrers
• Lab Shakers
• Lab Centrifuges
• Pipettes

We deliver products from trusted MFGs like:

• Ohaus
• Scilogex
• Being Instrument
• Radwag

Focusing on other industrial or scientific applications? You can depend on Lab.Equipment for much needed assistance. Raise workroom productivity and efficiency with lab equipment for other industries including microbiology, forensics, environmental, and more. Browse what you require for your application here.