Applied computational analyses are used in the identification of exRBPs in plasma, serum, saliva, urine, and cerebrospinal fluid. The predictions were further confirmed experimentally at about 80% in plasma and cell cultures in the lab. This suggested a high specificity for the computational method.
The results gathered allowed the researchers to come up with a map of candidate exRBPs and their corresponding exRNA cargo. This expands the landscape of potential biomarkers that can be examined in liquid biopsies to keep track for normal and disease processes.