Melanoma with In-frame Deletion of MAP2K1: A Distinct Molecular Subtype of Cutaneous Melanoma Mutually Exclusive from BRAF, NRAS, and NF1 Mutations

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While the genomics of BRAF, NRAS, and other key genes influencing MAP kinase (MAPK) activity have been thoroughly characterized in melanoma, mutations in MAP2K1 (MEK1) have received significantly less attention and have consisted almost entirely of missense mutations considered secondary oncogenic drivers of melanoma. Here, we investigated melanomas with in-frame deletions of MAP2K1, alterations characterized as MAPK-activating in recent experimental models. Our case archive of clinical melanoma samples with... More of this in the Modern Pathology Blog.

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