MERS Vaccine that Fully Protects Mice Used as Basis for Coronavirus Candidate

April 17, 2020 | Biotechnology

Reading time: 3 minutes

This week, Lab.Equipment has sourced a new Biotechnology article published from Genetic Engineering and Biotechnology News (GEN):

A vaccine that fully protects mice against a lethal dose of MERS-CoV, the coronavirus that causes Middle East respiratory syndrome (MERS) is being used by its developers at the University of Iowa (UI) and the University of Georgia as the foundation for a vaccine candidate against the pandemic SARS-CoV-2 virus, which is a close cousin to MERS-CoV.

The parainfluenza virus (PIV5)-based MERS vaccine is engineered to express the MERS-CoV envelope spike (S) protein that mediates viral entry into target cells. Preclinical in vivo tests with the vaccine in mice are reported in mBio, and demonstrated that just one... View the full article at the GEN Blog.

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