Mismatch Repair Deficiency in Uterine Carcinosarcoma: A Multi-institution Retrospective Review

May 20, 2020 | Histopathology

Reading time: 1 minute

Freshly released on AJSP, Lab.Equipment has sourced this noteworthy Pathology industry article just for you:

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is recommended in endometrial carcinomas as a screening test for Lynch syndrome, and mismatch repair deficiency (MMRd) is reported in ∼30% of cases. However, few studies have evaluated the rate of MMR loss in uterine carcinosarcomas. A 5-year retrospective database search of uterine carcinosarcomas was performed at 3 academic institutions. The histologic diagnoses, type of carcinoma present, and MMR IHC interpretations were confirmed by a gynecologic pathologist. One hundred three cases of uterine carcinosarcomas with available MMR IHC results were identified. Ninety-nine cases (96%) showed intact expression and 4 cases (4%) showed loss of MLH1/PMS2. All MMRd carcinosarcomas identified in this series had an endometrioid carcinomatous component and wild-type p53 expression. In contrast, the majority of MMR intact carcinosarcomas had a serous morphology and aberrant p53 expression. Three additional cases initially diagnosed as carcinosarcoma also revealed MMRd; however, given the lack of clear mesenchymal differentiation, these cases were reclassified as dedifferentiated endometrial carcinomas and were subsequently excluded from the carcinosarcoma category. No cases of Lynch syndrome were identified among carcinosarcoma patients, as all 4 MMRd cases were due to somatic MLH1 hypermethylation. In summary, we found that the rate of MMRd is markedly lower in uterine carcinosarcoma when compared with endometrial carcinoma. In the setting of MMR loss, a diagnosis of dediff... Want to read more? You can read the whole article in The American Journal of Surgical Pathology Blog.

If you are in the Surgical Pathology industry and are scouting for premium Pathology lab equipment for diagnosing diseases or doing biopsies or basic and advanced applications, then you are in the right place. Lab.Equipment distributes a range of products for workrooms analyzing and running several histophatological tests. Check out our highly-recommended Pathology equipment such as:

Find what your application needs by shopping our available products from well-trusted manufacturers including:

Accomplishing cannabis, veterinary, environmental applications? Rely on Lab.Equipment to help improve your productivity and efficiency. Shop accurate lab equipment for whatever application here.

Back To Top
We are fully compliant with the GDPR laws. We promise to safeguard your data and protect your privacy rights.