Oxidative Phosphorylation Promotes Primary Melanoma Invasion

For your weekly Histopathology news, Lab.Equipment has handpicked this notable article from The American Journal of Pathology for you:

Dermal invasion is a hallmark of malignant melanoma. Thought the molecular alterations driving the progression of primary melanoma to metastatic disease have been studied extensively, the early progression of non-invasive primary melanoma to an invasive state is poorly understood. To elucidate the mechanisms underlying the transition from radial to vertical growth, the first step in melanoma invasion, we developed a zebrafish melanoma model in which constitutive activation of ribosomal protein S6 kinase A1 (Rps6ka1; RSK1) drives tumor invasion.... More of this in the The American Journal of Pathology Blog.

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