Perivascular Fibro-adipogenic Progenitor Tracing During Post-traumatic Osteoarthritis

June 17, 2020 | Histopathology

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Perivascular mural cells surround capillaries and microvessels, and have diverse regenerative or fibrotic functions after tissue injury. Subsynovial fibrosis is a well known pathologic feature of osteoarthritis, yet transgenic animals to visualize perivascular cell contribution to fibrosis during arthritic changes have not been developed. Here, inducible Pdgfra-CreERT2 reporter mice were subjected to joint destabilization surgery in order to induce arthritic changes, and cell lineage traced over an 8 week period with a focus on the joint-associated fat pad.... Find the entire article at the The American Journal of Pathology Blog.

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