Placental Overexpression of Soluble CORIN in Preeclampsia

May 13, 2020 | Histopathology

First released on The American Journal of Pathology, check out today's noteworthy article for your Pathology industry news fix:

Preeclampsia (PE) is a hypertensive disease of pregnancy associated with substantial maternal and fetal morbidity and mortality. CORIN is a transmembrane type II serine protease expressed in cardiomyocytes that converts pro-atrial natriuretic peptide (pro-ANP) into ANP, a cardiac hormone that regulates blood pressure. High levels of soluble CORIN have been reported in preeclampsia and are supposed to be cardiac in origin. We hypothesized that during pregnancy soluble CORIN is released by the syncytiotrophoblast and that increased levels of soluble CORIN in preeclampsia originate from placenta... More of this in The American Journal of Pathology Blog.

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