Platelet C-type Lectin-like Receptor Reduces Cholestatic Liver Injury in Mice

For the latest news in the Histopath industry, you can always rely on Lab.Equipment as we publish articles from trusted online sources on a day-to-day basis. Here is a noteworthy entry acquired from The American Journal of Pathology:

Cholestatic liver injury leads to liver dysfunction. The available evidence suggests that platelets can either promote or reduce liver injury and fibrosis. We focused on the functions of the c-type lectin-like receptor (CLEC-2), a new special platelet receptor that binds with podoplanin activating platelets. We investigated the role of CLEC-2 and podoplanin in cholestatic liver injury. We injected mice intraperitoneally with weekly doses of anti-CLEC-2 antibody (2A2B10) to achieve effective CLEC-2 inhibition in their platelets... Want to read more? Visit The American Journal of Pathology​ Blog.

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