Possible SARS-CoV-2 Vulnerability Revealed by Human Antibody

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Gaining insight into how our immune system recognizes the SARS-CoV-2 virus is a key component to inform future drug design and vaccine development. A research group from the Scripps Research Institute has recently determined the crystal structure of CR3022—a neutralizing antibody previously isolated from a convalescent SARS patient—in complex with the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein to 3.1 Å.

The study, “A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV,” published in Science, is the first to map a human antibody’s interaction with SARS-CoV-2... Read the whole article at the GEN Blog.

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