Quantification of Viral and Host Biomarkers in the Liver of Rhesus Macaques: a Longitudinal Study of Zaire Ebolavirus strain Kikwit (EBOV/Kik)

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Zaire ebolavirus (EBOV) causes Ebola virus disease (EVD), which carries a fatality rate between 25-90% in humans. Liver pathology is a hallmark of terminal EVD; however, little is known about temporal disease progression. We utilized multiplexed fluorescent immunohistochemistry (mIHC) and in situ hybridization (mISH) in combination with whole slide imaging (WSI) and image analysis (IA) to quantitatively characterize temporospatial signatures of viral and host factors as related to EBOV pathogenesis... View the entire article at The American Journal of Pathology Blog.

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