Rare Genetic Variants from Birth Have Negative Effect on Lifespan

April 22, 2020 | Biotechnology

Reading time: 3 minutes

To keep you updated on the latest Bio Technology industry news, Lab.Equipment has handpicked this interesting article from Genetic Engineering and Biotechnology News (GEN) for you:

A new study from investigators at Brigham and Women’s Hospital and Harvard Medical School sheds new light on the risk of developing long-term diseases and overall human lifespan. The researchers found that the combined effects of rare, damaging mutations present at birth have a negative impact on healthspan and longevity.

Findings from the new study—published recently in eLife through an article titled “Germline burden of rare damaging variants negatively affects human healthspan and lifespan”—suggest one additional inherited damaging mutation could carve off six months of life, and combinations of these rare mutations determine how soon someone will develop diseases such as cancer, heart disease, and dementia.

Interestingly, most of the genetic variants linked to lifespan that researchers currently know about have been found in people who live long, such as centenarians who live to 100 or older. The variants responsible for the survival of the rest of the population remain... More of this in the GEN Blog.

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