Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis

Originally published on The American Journal of Pathology, here is a noteworthy article for your daily Histopathology news fix:

Within the human lung, mast cells typically reside adjacent to the conducting airway, and assume a “mucosal” phenotype (MCT). In rare pathological conditions, “connective tissue” phenotype mast cells (MCTC) can be found in the lung parenchyma. MCTC accumulate in the lungs of infants with severe bronchopulmonary dysplasia (BPD), a chronic lung disease associated with preterm birth, which is characterized by pulmonary vascular dysmorphia. The human LUVA mast cell line was used to model MCTC or MCT.... Read the full article at The American Journal of Pathology Blog.

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