SIRT1 Attenuates the Neurotoxicity Associated with Alzheimer’s Disease, via A Mechanism Which May Involve Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator 1-α

April 22, 2020 | Histopathology

For your weekly Pathology news, Lab.Equipment has handpicked this notable article from The American Journal of Pathology for you:

To investigate whether silent mating-type information regulation 2 homolog 1 (SIRT1) plays a neuroprotective role in connection with Alzheimer’s disease (AD), brain tissues from patients with AD and APP/PS1 mice as well as primary rat neurons exposed to oligomers of amyloid-β peptide (AβO) were used. The animals were treated with resveratrol (RSV) or suramin for two months; and cell cultures with RSV, suramin, the PGC-1α stimulator ZLN005 and transient transfection with PGC-1α RNA silence. The level of SIRT1 in brain tissues from patients with AD and APP/PS1 mice, as well as in primary neurons exposed to AβO was decreased, including SIRT1 proteins in nuclear or mitochondria.... Find the full article at the The American Journal of Pathology Blog.

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