Small-molecule drug allows for more efficient metabolism of sugar and fat

April 19, 2023 | Biology

Researchers from the University of Texas Health Science Center at San Antonio produced a drug that promotes efficient metabolism of sugar and fat in the mitochondria.

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The team first explored how magnesium affects metabolism. Being the fourth most abundant in the element, it plays fundamental roles in regulating blood sugar, blood pressure and building bones. However, too much magnesium in the blood slows energy production in the mitochondria.

Deleting the gene, MSR2, which supports magnesium transport into the mitochondria prevented weight gain and adverse liver changes in mice that were subjected to long-term dietary stress precipitated by a high-sugar and fatty Western diet.

CPACC, the compound that the researchers developed, accomplishes the same mechanism. The experiments still showed skinny yet healthy mice. Lowering the mitochondrial magnesium prevented the adverse effects of a high caloric diet including obesity, type II diabetes and cardiovascular complications.

After seeing significant and positive implications in healthcare, the researchers promised to continue the drug’s development. 

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