Spectrum of Hepatic Manifestations of Common Variable Immunodeficiency

April 29, 2020 | Histopathology

Reading time: 1-2 minutes

Handpicked by Lab.Equipment from AJSP, here is this week's Surgical Pathology industry article for you:

Common variable immunodeficiency (CVID) has a heterogenous clinical presentation and can be challenging to diagnose. Distinct histologic changes have been linked with CVID in several organ systems, which can help identify the correct diagnosis. In this study we review a cohort of hepatic CVID biopsies, to better define the spectrum of histologic and biochemical alterations. We reviewed 26 liver biopsies from 24 patients with CVID, obtained at 4 institutions between 2010 and 2019. Histologic slides were examined, and pathologic, biochemical, and clinical features were recorded. A control cohort of 21 patients with nodular regenerative hyperplasia (NRH) but lacking CVID was also examined. Liver function tests were frequently abnormal, especially alkaline phosphatase (median: 193 IU/L) and aspartate transaminase (median: 56 U/L), elevated in 23 and 17 of 25 biopsies, respectively. Fifteen patients had CVID involvement of other organs. Histologic features of primary biliary cholangitis were present in 2 patients, with florid duct lesions and prominent bile duct injury, in association with positive antimitochondrial antibodies. Among the other 24 biopsies, mild to moderate portal and lobular inflammation were present in 18 and 17 of 24 biopsies, respectively. Overall, 22 of 24 biopsies showed NRH-like changes. Plasma cell were absent. A distinct pattern of pericellular fibrosis was present in 23 of 26 biopsies overall. Involvement ranged from focal centrizonal fibrosis to bridging fibrosis and was accompanied by increased i... Want to read more? Visit the AJSP​ Blog.

If you're in the Pathology industry and are scouting for top quality Surgical Pathology lab equipment for your basic or advanced applications, then you have come to the right place. Lab.Equipment delivers a range of equipment for facilities running histophatological tests. Go through our highly-recommended Pathology equipment like:

Get valuable lab equipment for your application by shopping our product portfolio from globally recognized brands such as:

Focusing on other applications? You can rely on Lab.Equipment for much needed assistance. Boost laboratory productivity and efficiency with lab equipment for other industries including food testing, cannabis, chemistry, and more. Check out what you need for your application here.

Back To Top
We are fully compliant with the GDPR laws. We promise to safeguard your data and protect your privacy rights.