Spontaneous Development of Hepatocellular Carcinoma and B-cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein (Bccip) Knockout Mice

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Hepatocellular carcinoma (HCC) is the most common form of liver tumors. Although HCC is associated with chronic viral infections, alcoholic cirrhosis, and non-alcoholic fat liver disease, genetic factors that contribute to the HCC risk remain unknown. The BRCA2 DNA repair associated (BRCA2) and cyclin dependent kinase inhibitor 1A (CDKN1A) interacting protein, known as BCCIP, are essential for cell viability and maintenance of genomic stability. In this study, we established a new genetically engineered mouse model with Bccip deficiency... View the entire article at The American Journal of Pathology Blog.

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