Sustained Hedgehog Signaling in Medulloblastoma Tumoroids is Attributed to Stromal Astrocytes and Astrocyte-derived Extracellular Matrix

June 03, 2020 | Histopathology

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Medulloblastoma (MB) cells form three-dimensional tumoroids in vitro that can be passaged and preserved. MB cells in tumoroids retain the tumorigenic potential and hedgehog signaling, which relies on stromal astrocytes and astrocyte-derived extracellular matrix. These findings provide a valuable cell model for the basic and preclinical studies of MB... You can read the full article in the Laboratory Investigation Blog.

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